Serum calcium and creatinine levels should be determined at 1, 3 and 6 months and at 6 monthly intervals thereafter.Ĭlinical experience with Rocaltrol in elderly patients indicates that the dosage recommended for use in younger adults may be given without apparent ill-consequence. The recommended dose of Rocaltrol is 0.25 mcg twice daily. A maximum total cumulative dosage of 12 mcg per week should not be exceeded. See section 4.5 for details of dose adjustments related to drug interactions.Īn oral Rocaltrol pulse therapy with an initial dosage of 0.1 mcg/kg/week split into two or three equal doses given at the end of the dialysis has been shown to be effective in patients with osteodystrophy refractory to continuous therapy. Most patients respond to between 0.5 mcg and 1.0 mcg daily. Should the serum calcium levels rise to 1 mg/100ml (250 µmol/l) above normal (9 to 11 mg/100 ml or 2250 – 2750 µmol/l), or serum creatinine rises to > 120 µmol/l, treatment with Rocaltrol should be stopped immediately until normocalcaemia ensues. During this period, serum calcium levels should be determined at least twice weekly. If no satisfactory response in the biochemical parameters and clinical manifestations of the disease is observed within 2 - 4 weeks, the daily dosage may be increased by 0.25 mcg at 2 - 4 week intervals. ![]() In patients with normal or only slightly reduced calcium levels, doses of 0.25 mcg every other day are sufficient. The initial daily dose is 0.25 mcg of Rocaltrol. The capsules should be swallowed with a little water. ![]() The effectiveness of treatment depends in part on an adequate daily intake of calcium, which should be augmented by dietary changes or supplements if necessary. The dose of Rocaltrol should be carefully adjusted for each patient according to the biological response so as to avoid hypercalcaemia.
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